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Abstract
Case Report
A case of interstitial pneumonia with progressive pulmonary hypertension and anti-Th/To antibodies found while taking nintedanib
Kanako Tamura Hidetaka Tanabe Keijirou Yamauchi Masashi Yokoyama Takafumi Yanase Hiroshi Morishita
Department of Respiratory Medicine, Osaka Prefectural Hospital Organization Osaka Habikino Medical Center
ABSTRACT
A 65-year-old man had been taking nintedanib for 6 years for idiopathic interstitial pneumonia. He developed pulmonary hypertension, but this was considered to be group 3 pulmonary hypertension and he was not started on pulmonary vasodilators. A physical examination revealed dermatosclerosis of his fingertips, and unmeasured scleroderma-associated antibodies were submitted, which were found to be positive for anti-Th/To antibodies. The patient was diagnosed with group 1 pulmonary hypertension caused by systemic scleroderma and was treated with selective pulmonary vasodilators at a different hospital specialized in pulmonary circulation, and his condition improved. In the treatment of interstitial pneumonia, it is necessary to review physical examination findings and autoantibodies as appropriate to detect any collagen disease that may have been overlooked.
KEYWORDS
Nintedanib Interstitial pneumonia Systemic sclerosis Pulmonary arterial hypertension Anti-Th/To antibodies
Received 24-Apr-24 ／ Accepted 29-May-24
AJRS, 13(5): 223-227, 2024
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