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Article in Japanese
Abstract
Original Article
A retrospective study of 11 patients with refractory Mycobacterium avium complex pulmonary disease treated with amikacin liposome inhalation suspension
Hideto Oshitaa Yasuhiko Ikegamia Misato Ogataa Asami Inouea Yuka Sanoa Koji Yoshiokaa Eiji Miyaharab Naoki Yamaokaa
aDepartment of Respiratory Medicine, Federation of National Public Service and Affiliated Personnel Mutual Aid Associations, Yoshijima Hospital
bDepartment of Respiratory Surgery, Federation of National Public Service and Affiliated Personnel Mutual Aid Associations, Yoshijima Hospital
ABSTRACT
We retrospectively analyzed 11 patients with Mycobacterium avium complex (MAC) pulmonary disease treated with amikacin liposome inhalation suspension (ALIS). We investigated the clinical characteristics associated with the bacteriological efficacy of ALIS, including the number of acid-fast bacilli from sputum and imaging findings. Culture conversion was confirmed in 4 out of 11 cases, of which 2 were macrolide-resistant cases. NICE score values of the culture conversion cases for total score, cavity, and upper lung fields were significantly lower. In addition, the culture conversion cases had a smaller number of acid-fast bacilli from sputum and a lower inflammatory response. The number of acid-fast bacilli from sputum, inflammatory response, and the distribution/morphology of lung lesions before ALIS initiation could affect the efficacy of ALIS.
KEYWORDS
Amikacin liposome inhalation suspension (ALIS) Non-tuberculous mycobacterial pulmonary disease (NTM-PD) Culture conversion NICE score
Received 25-Apr-24 ／ Accepted 26-Jun-24
AJRS, 13(5): 203-207, 2024
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