Annals of The Japanese Respiratory Society:A case of peptide receptor radionuclide therapy for postoperative recurrence of a pulmonary carcinoid

Vol.13 No.2 Table of Contents

Abstract

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Article in Japanese

Case Report

A case of peptide receptor radionuclide therapy for postoperative recurrence of a pulmonary carcinoid

Yuma Sato^a Jun Sakakibara^a Toshihiro Kuroki^a Yoshihiro Matsuno^b Kenji Hirata^c Satoshi Konno^a

^aDepartment of Respiratory Medicine, Faculty of Medicine, Hokkaido University
^bDepartment of Surgical Pathology, Hokkaido University Hospital
^cDepartment of Diagnostic Imaging, Hokkaido University Graduate School of Medicine

ABSTRACT

A 47-year-old male patient underwent a right lung middle lobectomy 9 years ago for a typical carcinoid tumor. The carcinoid recurred 4 years later with liver metastases. He was treated with everolimus followed by chemotherapy, but the disease progressed after these treatments. Positive uptake was observed in liver metastasis on somatostatin receptor scintigraphy. Moreover, liver metastasis and the primary resected tumor were positive for somatostatin receptor (SSTR) 2 in immunohistochemistry. After he had received four cycles of Lutetium-177(¹⁷⁷Lu)-DOTATATE, the liver metastases shrank, and the effect of treatment has been maintained for more than 1 year. ¹⁷⁷Lu-DOTATATE is a promising treatment method.

KEYWORDS

Pulmonary carcinoid Peptide receptor radionuclide therapy (PRRT) Somatostatin receptor

Received 19 Sep 2023 ／ Accepted 24 Nov 2023

AJRS, 13(2): 49-53, 2024

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