A case of pleuroparenchymal fibroelastosis with Crohn's disease
Yuko Nitta Yoshifumi Yamamoto Takao Osa Masahide Ohta Shigeto Hontsu Shigeo Muro
Department of Respiratory Medicine, Nara Medical University
A 47-year-old man presented for evaluation of fever and cough. He reported a history of Crohn's disease and had been receiving mesalazine and infliximab therapy for 10 years. Chest computed tomography revealed decreased upper lobe volume, a right lobe apical cavity, and bilateral ground-glass opacification and consolidation. The patient was diagnosed with pleuroparenchymal fibroelastosis (PPFE) based on clinical and radiological findings. Aspergillus fumigatus was identified in bronchial lavage fluid culture, and a diagnosis of chronic pulmonary aspergillosis was made. Crohn's disease may be complicated by pulmonary manifestations including PPFE. In addition, it is necessary to consider infections and drug-induced lung injury in patients receiving immunosuppressive treatment for Crohn's disease.
Crohn's disease (CD) Chronic pulmonary aspergillosis (CPA)
Received 17 Nov 2022 / Accepted 18 Apr 2023
AJRS, 12(4): 196-200, 2023