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Article in Japanese
Abstract
Case Report
A case of allergic bronchopulmonary mycosis that developed during treatment with nivolumab
Yoshifumi Nishimuraa Rika Sanadab Yasuhiko Nakaa Kentaro Kawaguchia Kozue Miyazakia Katsuhiko Kameic
aDepartment of Respiratory Medicine, National Hospital Organization Higashihiroshima Medical Center
bDepartment of Internal Medicine, Shobara Red Cross Hospital
cMedical Mycology Research Center, Chiba University
ABSTRACT
A 70-year-old female with respiratory symptoms of coughing and sputum underwent bronchoscopy after chest computed tomography (CT) revealed consolidation and mucus plugs in the right lower lobe of her lung, during treatment with nivolumab. Fungal hyphae were present in the bronchial mucus plugs, and Schizophyllum commune was cultured from the bronchial lavage fluid. We diagnosed the patient with allergic bronchopulmonary mycosis based on the following diagnostic criteria: peripheral blood eosinophilia; a positive result for specific immunoglobulin E test against S. commune; central bronchiectasis, and high attenuation mucus plugs on chest CT.
KEYWORDS
Immune checkpoint inhibitor Allergic bronchopulmonary mycosis (ABPM) Schizophyllum commune Antifungal therapy Mepolizumab
Received 31 Jan 2022 ／ Accepted 9 May 2022
AJRS, 11(4): 198-201, 2022
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