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Article in Japanese
Abstract
Case Report
Rapidly progressive interstitial lung disease with antimitochondrial antibody-positive myositis: a case study
Akio Nomuraa Kosuke Hamaib Hiroki Kobayashic Takuya Tanimotob Hiroyuki Maedad Nobuhisa Ishikawab
aDepartment of Respiratory Medicine, Hiroshima University
bDepartment of Respiratory Medicine, Hiroshima Prefectural Hospital
cDepartment of Rheumatology, Hiroshima University
dDepartment of Rheumatology, Hiroshima Prefectural Hospital
ABSTRACT
A 72-year-old woman receiving corticosteroid therapy for antimitochondrial antibody-positive myositis was admitted with dyspnea. Contrast-enhanced chest computed tomography showed ground-glass shadows and infiltrative shadows in all lung fields at the time of admission, suggesting rapidly progressive interstitial lung disease (RP-ILD) associated with myositis. In addition to corticosteroid pulse therapy and antibacterial drug administration, respiratory management with high-flow nasal cannula was performed; however, artificial respiration management was required because of progressive respiratory failure. Subsequently, cyclophosphamide pulse therapy was used in combination, but there was no improvement, and she died 31 days after admission. This is considered to be a valuable case as there are no reports of antimitochondrial antibody-positive myositis combined with RP-ILD.
KEYWORDS
Antimitochondrial antibody-positive myositis Rapidly progressive interstitial lung disease (RP-ILD) Corticosteroid pulse therapy Cyclophosphamide pulse therapy
Received 25 Jan 2021 ／ Accepted 25 May 2021
AJRS, 10(4): 358-362, 2021
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