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Article in Japanese
Abstract
Case Report
A case of granulomatosis with polyangiitis coinciding with asbestosis
Ken Shirahasea Osamu Nishiyamaa Takashi Oomoria Sho Saekia Shigeki Shimizub Yuji Tohdaa
aDepartment of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine
bDepartment of Pathology, Kinki Central Hospital of the Mutual Aid Association of Public School Teachers
ABSTRACT
An 84-year-old man with asbestosis presented with newly developed infiltrates in bilateral lower lobes that were superimposed on existing shadows of asbestosis on his chest computed tomography (CT). Histological findings of lung specimens that were obtained from the new infiltrates with transbronchial forceps showed that neutrophil infiltration was destroying pulmonary vessels, indicating vasculitis. With myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) positivity, he was diagnosed with granulomatosis with polyangiitis (GPA). The patient is, to our knowledge, the first reported coincident case of asbestosis and GPA, indicating significant relationships among pneumoconiosis, ANCA production, and vasculitis.
KEYWORDS
Asbestosis Granulomatosis with polyangiitis (GPA) Interstitial lung disease Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)
Received 18 Jul 2020 ／ Accepted 24 Nov 2020
AJRS, 10(2): 178-182, 2021
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