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Article in Japanese
Abstract
Case Report
A case of suspected drug-induced lung disease caused by encorafenib and binimetinib
Nozomi Goto* Atsushi Iijima Satoshi Mikami Kimihiko Nagasaki Tomoaki Ota Naoya Ozawa
Department of Respiratory Medicine, Chutoen General Medical Center
*Present address: Department of Respiratory Medicine, Japanese Red Cross Nagoya Daiichi Hospital
ABSTRACT
A 73-year-old man was administered combination therapy with encorafenib/binimetinib (BRAF/MEK inhibitors) beginning in April 20XX. Two months later, owing to medication-induced nausea, he discontinued this medication for one month. He developed cough and dyspnea one week after he resumed medication intake, and chest computed tomography revealed ground-glass opacities in both lungs. Administration of steroid pulse therapy and mechanical ventilation resulted in improved symptoms and imaging findings, and we diagnosed the patient with drug-induced (encorafenib/binimetinib combination) lung disease. To our knowledge, this is a rare report of drug-induced lung disease secondary to encorafenib/binimetinib administration.
KEYWORDS
Encorafenib Binimetinib Drug-induced lung disease
Received 8 Sep 2020 ／ Accepted 16 Nov 2020
AJRS, 10(2): 144-148, 2021
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