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Article in Japanese
Abstract
Case Report
Effective administration of mycophenolate mofetil in anti-MDA5 antibody-positive, rapidly progressive, interstitial lung disease: a case report and literature review
Ami Iwai Kazuyuki Tsujino Yuji Yamamoto Tomoki Kuge Reina Hara Hiroshi Kida
Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center
ABSTRACT
A 75-year-old man presented with progressive respiratory failure. He was diagnosed with anti-MDA5 antibody-positive, rapidly progressive interstitial lung disease. We immediately initiated combination therapy with high-dose corticosteroids, tacrolimus, and intravenous cyclophosphamide (IVCY). However, IVCY could not be continued because of the hypoxemia and fever repeatedly observed after administration of IVCY. We switched from IVCY to mycophenolate mofetil (MMF), and thereafter the serum values of ferritin, KL-6, and SP-D gradually decreased alongside an improvement in his respiratory condition. High-flow nasal cannula treatment was withdrawn, and he was discharged from hospital. Since the efficacy and safety of MMF for this disease have never been determined, a review of the literature is also presented.
KEYWORDS
Interstitial lung disease Anti-MDA5 antibody Dermatomyositis Mycophenolate mofetil (MMF)
Received 20 Nov 2019 ／ Accepted 8 Jan 2020
AJRS, 9(3): 205-210, 2020
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