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Article in Japanese
Abstract
Case Report
A case of drug-induced lung injury induced by abiraterone acetate linked to serum heme oxygenase-1
Kayo Haritaa Yu Haraa Kota Murohashia Ryo Nagasawaa Koji Okudelab Takeshi Kanekoa
aDepartment of Pulmonology, Yokohama City University Graduate School of Medicine
bDepartment of Pathology, Yokohama City University Graduate School of Medicine
ABSTRACT
Heme oxygenase-1 (HO-1) is a heme-degrading enzyme with antioxidant activity and has been reported to be useful for the diagnosis and prognosis prediction of interstitial pneumonia. The case was an 83-year-old male. The patient was hospitalized for drug-induced lung injury due to abiraterone acetate used to treat prostate cancer. Although the patient’s condition stabilized temporarily after steroid pulse therapy, the lung injury was aggravated due to influenza A infection during steroid titration. He died without improvement. This case is very rare, in that serum HO-1 levels not only showed changes similar to those of KL-6 and SP-D, but also were more closely linked to disease activity than both biomarkers. We also report the distribution and degree of HO-1 expression in lung cells.
KEYWORDS
Abiraterone acetate Biomarker Diffuse alveolar damage (DAD) Drug-induced lung injury Heme oxygenase-1 (HO-1)
Received 21 Oct 2019 ／ Accepted 19 Dec 2019
AJRS, 9(2): 141-146, 2020
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