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Article in Japanese
Abstract
Case Report
A case of herpes simplex encephalitis that developed during chemotherapy for small cell lung cancer and required differentiation from paraneoplastic limbic encephalitis
Akiko Okuyamaa Hideaki Yamasawab Masafumi Sataa Takuji Suzukia Satoshi Kitamurac Kouichi Hagiwaraa
aDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University
bDivision of Pulmonary Medicine, International University of Health and Welfare Hospital
cMinami-Tochigi Hospital
ABSTRACT
A 67-year-old man with small cell lung cancer responded well to secondary chemotherapy, but he developed disturbance of consciousness and a new lesion in the longitudinal fissure of the right frontal lobe cortex. The cerebral lesion further extended into the bilateral cingulate gyrus on day 6 of the illness and it was diagnosed as limbic encephalitis. Although he was treated with acyclovir and intravenous immunoglobulin therapy, he died without improvement in consciousness. It was later revealed that he was positive for herpes simplex virus-DNA in his cerebrospinal fluid, and thus he was diagnosed as having herpes simplex encephalitis. Therefore, it is important to actively seek other underlying diseases than paraneoplastic diseases when limbic encephalitis occurs under anticancer therapy.
KEYWORDS
Small cell lung cancer Limbic encephalitis Herpes simplex encephalitis Paraneoplastic limbic encephalitis
Received 24 Jun 2019 ／ Accepted 4 Oct 2019
AJRS, 9(1): 28-32, 2020
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