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Article in Japanese
Abstract
Case Report
An autopsy case of EGFR mutation-positive combined small-cell lung carcinoma with squamous cell carcinoma
Yasutaka Onishia Tetsuji Kawamuraa Rokuro Mimurab Ryota Hiraokaa Sayaka Takahashia Yasuharu Nakaharaa
aDepartment of Respiratory Medicine, National Hospital Organization Himeji Medical Center
bDepartment of Diagnostic Pathology, National Hospital Organization Himeji Medical Center
ABSTRACT
A 74-year-old female non-smoker complaining of cough and hemoptysis was admitted to our hospital with an abnormal shadow on chest X-ray. The diagnosis was combined small-cell lung carcinoma (C-SCLC) with squamous cell carcinoma (cT3N1M1b, stage IV, single brain metastasis). Screening for epidermal growth factor receptor (EGFR) gene mutations revealed an exon 21 L858R mutation. The patient showed a partial response after the initiation of gefitinib. Herein we report a rare case of EGFR mutation-positive C-SCLC with squamous cell carcinoma along with EGFR gene mutation that responded to treatment with an EGFR tyrosine-kinase inhibitor (EGR-TKI).
KEYWORDS
Combined small-cell lung carcinoma (C-SCLC) Squamous cell carcinoma Epidermal growth factor receptor (EGFR) mutation EGFR tyrosine-kinase inhibitor (EGFR-TKI)
Received 22 May 2019 ／ Accepted 2 Aug 2019
AJRS, 8(6): 405-409, 2019
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