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Article in Japanese
Abstract
Case Report
A case of Good syndrome accompanied by a macrolide-resistant diffuse panbronchiolitis-like symptoms
Masamitsu Shimizu Yoshinobu Saito Yukiko Miura Yuji Minegishi Arata Azuma Akihiko Gemma
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
ABSTRACT
The patient was a 50-year-old woman diagnosed with myasthenia gravis and thymoma who was being treated with radiochemotherapy, steroid administration, and immunosuppressive therapy after thymectomy. Approximately 5 years after the diagnosis, productive cough developed and centrilobular granular shadows in both lung fields were observed by chest contrast-enhanced computed tomography (CT). Diffuse panbronchiolitis (DPB) was ruled out by a negative HLA-B54 gene test result. Her condition was associated with hypogammaglobulinemia due to a decreased B-cell count.
Good syndrome complicated by DPB-like symptoms was diagnosed. We report this case because macrolide-resistant cases, such as that of our current patient, are rare.
KEYWORDS
Good syndrome Hypogammaglobulinemia Diffuse panbronchiolitis HLA-B54 gene Macrolide therapy
Received 27 Jul 2017 ／ Accepted 13 Feb 2018
AJRS, 7(3): 171-176, 2018
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