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Abstract
Case Report
A case of spontaneous regression of small cell lung cancer with anti-Hu-antibody-positive paraneoplastic neurological syndrome
Yusuke Hamakawa Shinichiro Ota Maiko Awashima Yuji Fujikura Soichiro Kanoh Akihiko Kawana
Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College
ABSTRACT
A 76-year-old man presented with depression, irritation, fatigue, and nausea. Unenhanced computed tomography of the chest revealed a nodule in the right lower lobe, with right mediastinal and hilar lymph node enlargement. The patient was referred to our hospital for further examination.
When the patient was admitted to our hospital, the nodule showed spontaneous regression. Small cell carcinoma cells were detected on endobronchial ultrasound-guided transbronchial needle aspiration.
During hospitalization, the patient developed acute cerebellar ataxia and disorientation. He tested positive for the anti-Hu antibody. Clinical and laboratory findings led to a diagnosis of paraneoplastic neurologic syndrome.
Spontaneous regression is thought to be caused by autoimmune processes triggered by anti-neuronal autoantibodies.
KEYWORDS
Small cell lung cancer Paraneoplastic neurologic syndrome Anti-Hu antibody Spontaneous regression
Received 8 Dec 2017 ／ Accepted 15 Feb 2018
AJRS, 7(3): 146-150, 2018
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