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Article in Japanese
Abstract
Case Report
A case of clinically diagnosed pulmonary cryptococcosis with Cushing’s syndrome
Tomoko Terada Yoshihisa Nukui Manabu Sema Yu Kusaka Tsukasa Okamoto Naohiko Inase
Department of Respiratory Medicine, Tokyo Medical and Dental University
ABSTRACT
There are limited reports of pulmonary cryptococcosis in patients with Cushing’s syndrome. We report the case of a 23-year-old woman with suspected Cushing’s syndrome. She underwent diagnostic imaging, with chest non-contrast computed tomography (CT) revealing a 7 mm irregular nodule. Sputum culture, sputum cytology, serum antigen levels of mycoses, and interferon-gamma release assays (IGRA) were negative. A chest non-contrast CT scan three weeks later revealed that the nodule had grown to 21 mm, and the cryptococcal antigen titer was now positive. The patient was diagnosed with pulmonary cryptococcosis and treated with fluconazole, which resulted in the disappearance of the nodule. Pulmonary cryptococcosis with Cushing’s syndrome is rare, and caution must be taken since serum cryptococcal antigen titers may be negative when the nodules on CT are small.
KEYWORDS
Pulmonary cryptococcosis Cushing’s syndrome Lung nodule Serum cryptococcal antigen
Received 8 Sep 2017 ／ Accepted 10 Nov 2017
AJRS, 7(1): 44-48, 2018
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