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Article in Japanese
Abstract
Case Report
A case of Wernicke’s encephalopathy that developed during treatment for lung cancer
Kenji Morimotoa Mai Komorib Koji Datea Hidehiko Kawanoa
aDepartment of Pulmonary Medicine, Kyoto Chubu Medical Center
bDepartment of General Internal Medicine, Kyoto Chubu Medical Center
ABSTRACT
An 82-year-old woman was diagnosed with epidermal growth factor re-ceptor (EGFR)-mutation-positive lung adenocarcinoma Stage IV and was treated with gefitinib. She experienced disorientation, cerebellar ataxia, and horizontal nystagmus during treatment. Magnetic resonance imaging (MRI) of the brain with fluid-attenuated inversion recovery sequence showed an area of high-signal intensity in the periventricular-periaqueductal gray region of the third ventricle, and Wernicke’s encephalopathy was diagnosed. Symptoms promptly improved on vitamin B1 ad-ministration. Malignant tumors are a risk factor for the development of Wernicke’s encephalopathy, but reports in lung cancer patients are rare. This could be due to inaccurate diagnosis.
KEYWORDS
Lung cancer Wernicke’s encephalopathy Vitamin B1 deficiency
Received 24 Mar 2017 ／ Accepted 7 Aug 2017
AJRS, 6(6): 450-453, 2017
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