Annals of The Japanese Respiratory Society:Acute myeloid leukemia following long-term chemotherapy with pemetrexed for non-small cell lung carcinoma

Abstract

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Article in Japanese

Case Report

Acute myeloid leukemia following long-term chemotherapy with pemetrexed for non-small cell lung carcinoma

Tomohiro Tanaka^a Koichiro Nozaki^b Hikaru Mamizu^a Takeshi Ohta^a Toshiki Furukawa^a Takashi Ishida^a

^aDepartment of Internal Medicine, Niigata Prefectural Hospital
^bDepartment of Internal Medicine, Niigata Cancer Hospital

ABSTRACT

We report a case of a 77-year-old male who presented with a metastatic pulmonary adenocarcinoma. The patient was administered a carboplatin and gemcitabine regimen. After a year, a loco-reginal relapse was revealed. Treatment with pemetrexed was used and achieved partial response. After 65 cycles of chemotherapy, the patient underwent complaints of general fatigue. A laboratory test revealed pancytopenia. Though we treated it with G-CSF many times, the pancytopenia made no improvement. Bone marrow aspiration biopsy confirmed a diagnosis of acute myeloid leukemia. The cytogenetic study revealed 11q23. Here we reported a case of acute myeloid leukemia after long-term treatment by pemetrexed.

KEYWORDS

Pemetrexed Secondary leukemia Secondary cancer

Received 19 Apr 2017 ／ Accepted 4 Jul 2017

AJRS, 6(5): 351-354, 2017

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Abstract

Case Report

ABSTRACT

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