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Article in Japanese
Abstract
Case Report
A case of malignant pleural mesothelioma complicated with familial Mediterranean fever
Soichiro Kona Sumito Inoueb Akira Igarashib Yoshikane Tokairinb Yoko Shibatab Isao Kubotab
aPostgraduate Clinical Training Center, Yamagata University Hospital
bDepartment of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine
ABSTRACT
A 61-year-old man, suffering from recurrent pleuritis or peritonitis, was diagnosed as familial Mediterranean fever (FMF) because of the mutation of Mediterranean fever (MEFV) gene. Even though he was treated by colchicine to reduce inflammation and prevent attack, he repeated the morbidity to the pleuritis and peritonitis. A biopsy was performed by using a video-assisted thoracic scope against the thickened pleura in which FDG-PET had strongly accumulated. Results of immunohistochemical staining (positive for calretinin, WT-1, and D2-40, negative for CEA and TTF-1) indicated the presence of malignant pleural mesothelioma. Because this case has never been exposed to asbestos, recurrent pleural inflammation resulting from FMF may cause malignant mesothelioma. We report an extremely rare case of malignant pleural mesothelioma complicated with FMF.
KEYWORDS
Malignant pleural mesothelioma Asbestos Familial Mediterranean fever
Received 23 Mar 2016 ／ Accepted 19 Dec 2016
AJRS, 6(3): 195-199, 2017
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