Full Text of PDF (655k)
Article in Japanese
Abstract
Case Report
A case of pulmonary toxicosis with a variety of pathological findings resulting from carbamazepine
Junichi Ogawaa Kouhei Yamauchib
aDepartment of Respiratory Medicine, Kitakami Saiseikai Hospital
bDivision of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine
ABSTRACT
We report a case of pneumonitis induced by carbamazepine. A 35-year-old woman began to complain of cough dyspnea and fever 20 days after starting to take carbamazepine for schizophrenia. Chest radiograph showed diffuse ground-glass shadows in the bilateral middle- and lower-lung fields. Chest CT showed diffuse ground-glass opacities in both lung fields. A video-assisted thoracic surgery specimen showed eosinophilic infiltration into the blood vessels, desquamative alveolar lining cells, and a portion of the alveolar septa; perivascular interstice are replaced by epitheloid cell granuloma. Based on a diagnosis of carbamazepine-induced pneumonitis, carbamazepine was discontinued, and her respiratory condition then improved. We discuss the important topic of the carbamazepine-induced pneumonitis development mechanism.
KEYWORDS
Carbamazepine Pulmonary toxicosis
Received 26 Sep 2016 ／ Accepted 27 Feb 2017
AJRS, 6(3): 180-185, 2017
Copyright © The Japanese Respiratory Society All Rights Reserved.