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Abstract
Original Article
Comparison of false-negative results between the T-SPOT®.TB assay with T-cell Xtend® reagent and QuantiFERON-TB Gold In-Tube test
Makoto Nakaoa Hideki Muramatsua Yuto Suzukia Yusuke Sakaia Yusuke Kagawaa Ryota Kurokawaa Naoyuki Itob Akiyo Morotob Sakiko Fujimotoc Hidefumi Satoa
aDepartment of Respiratory Medicine, Kainan Hospital Aichi Prefectural Welfare Federation of Agricultural Cooperatives
bDepartment of Clinical Laboratory, Kainan Hospital Aichi Prefectural Welfare Federation of Agricultural Cooperatives
cDepartment of Infection Control and Prevention, Kainan Hospital Aichi Prefectural Welfare Federation of Agricultural Cooperatives
ABSTRACT
A recent study showed that the proportion of patients with active tuberculosis who demonstrate a false-negative result on the T-SPOT®.TB assay conducted with the T-cell Xtend® reagent (T-SPOT with TCX) might be high. In patients with active tuberculosis, we compared the proportion of false-negative results between T-SPOT with TCX and QuantiFERON-TB Gold In-Tube test (QFT-3G). Among 121 patients with culture-positive active tuberculosis diagnosed at Kainan Hospital during the study period, 55 underwent testing with either T-SPOT with TCX (N=37 patients) or QFT-3G (N=18 patients). In the T-SPOT with TCX group, 9 patients had false-negative results; however, in the QFT-3G group no patients had false-negative results. The proportion of patients with false-negative results for T-SPOT with TCX might be higher than that for QFT-3G.
KEYWORDS
IGRA T-SPOT QFT-3G Active tuberculosis False-negative
Received 11 Jan 2017 ／ Accepted 21 Feb 2017
AJRS, 6(3): 115-121, 2017
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