Full Text of PDF (514k)
Article in Japanese
Abstract
Case Report
A case of transformation to small-cell lung cancer as an acquired resistance in EGFR-mutant lung adenocarcinoma after treatment with epidermal growth factor receptor-tyrosine kinase inhibitor
Yuichiro Araki Mamiko Kuriyama Masayoshi Morishita Akiko Harata Akinori Ishihara Hiroyoshi Maeda
Department of Respiratory Medicine, Nagoya City East Medical Center
ABSTRACT
A 67-year-old man had been diagnosed with lung adenocarcinoma T4N2M1b Stage IV with EGFR mutation (exon 19 deletion) and received some EGFR-tyrosine kinase inhibitors and chemotherapies. However, enhancement of the left pleural dissemination had been getting progressively worse. Examination of a CT-guided needle biopsy specimen showed positive staining for CD56, suggesting that the mass was a small-cell lung cancer (SCLC). Furthermore, we performed an EGFR mutation test using the same specimens, revealing that the SCLC tumor had an original EGFR exon 19-deletion mutation. Therefore we confirmed that the tumor had a transformation from EGFR-mutant adenocarcinoma to SCLC as an acquired resistance after EGFR-TKI treatment. We report transformation to SCLC, which is a relatively rare acquired resistance, with a review of relevant literature.
KEYWORDS
EGFR-mutant adenocarcinoma EGFR-TKI Transformation to SCLC Acquired resistance
Received 8 Jul 2016 ／ Accepted 28 Oct 2016
AJRS, 6(2): 99-103, 2017
Copyright © The Japanese Respiratory Society All Rights Reserved.