An 86-year-old woman with polymyalgia rheumatica had been treated with oral prednisolone. During her hospitalization for lumbar compression fracture, she developed deep vein thrombosis; subsequently, she was referred to our hospital. On admission, chest radiography revealed a cavity with infiltrates in the right upper lung; subsequently, sulbactam/ampicillin and tazobactam/piperacillin were administered. Bronchoscopy was performed and endobronchial sputum culture revealed positive for MSSA, Klebsiella pneumoniae, and Burkholderia cenocepacia. However, the lung abscess progressed. Endobronchial drainage was performed by using bronchial lavage fluid sample tested positive for B. cenocepacia showing its persistent infection. Treatment with both meropenem and endoscopic abscess drainage was successful in this case. In general, although lung infection due to B. cenocepacia is critical and usually fatal in immunocompromised patients, such as lung transplant recipients, it is rarely reported in Japan. Recently, the number of lung transplantation cases has increased in Japanese facilities. It is important to recognize the virulence of B. cenocepacia in immunocompromised patients in Japanese facilities.