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Article in Japanese
Abstract
Case Report
A case of nivolumab-induced interstitial pneumonia in a patient with melanoma
Hiroaki Ogata Naoki Hamada Norio Yamamoto Isamu Okamoto Koichiro Matsumoto Yoichi Nakanishi
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
ABSTRACT
A 56-year-old woman with recurrent malignant melanoma received vemurafenib for 5 months and thereafter received nivolumab 2 mg/kg every 3 weeks as a second-line therapy. After 8 courses (6 months) of nivolumab therapy, KL-6 was significantly elevated. A chest computed tomography scan revealed multiple ground-glass opacities and consolidations, and bronchoalveolar lavage fluid showed increased lymphocytes. Thus she was diagnosed with nivolumab-induced interstitial pneumonia and was treated with prednisolone 40 mg daily. After prednisolone was initiated, interstitial pneumonia promptly improved. Physicians should be aware of such risks and monitor nivolumab-treated patients accordingly.
KEYWORDS
Malignant melanoma Drug-induced interstitial pneumonia Organizing pneumonia Nivolumab Anti-PD-1 antibody
Received 1 Jul 2016 ／ Accepted 5 Oct 2016
AJRS, 6(1): 32-36, 2017
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