A 73-year-old man who had engaged in tire manufacturing until the age of 60 visited our outpatient clinic because of a chest X-ray film abnormality pointed by medical checkup. We diagnosed asbestos-related pleuropulmonary disease based on the existence of pleural plaques and interstitial pneumonia. He received periodic follow-up by thoracic CT. At the age of 76, an enlargement of a right-lower lobular nodule was recognized, and positron emission tomography suggested cT1bN0M0-equivalent uptake. He received a right-lower lobectomy in another hospital, and the pathological diagnosis was squamous cell lung carcinoma, pT3N1M0. Two months later, he was taken to our hospital in an ambulance because of a loss of consciousness. Although his consciousness was recovered, thoracic CT indicated multiple osteolyses and multiple low attenuation areas in the liver. He died after 14 days, and the autopsy revealed extended pleural plaques, pulmonary fibrosis, multiple bone metastases, and multiple hepatic metastases. Despite periodic follow-up, the course after the suspicion of lung cancer was only 9 months. Asbestos-related pleuropulmonary disease caused by tire manufacturing is quite rare, and the way to follow up asbestos-related diseases to discover the occurrence of malignancies should be reconsidered.