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Article in Japanese
Abstract
Original Article
Efficacy and safety of pleurodesis using OK-432 or talc in patients with malignant pleural effusion: A retrospective, single-center study
Kenichi Kobayashi Masahiro Seike Akiko Takahashi Kenichiro Atsumi Susumu Takeuchi Masaru Matsumoto Rintarou Noro Yuji Minegishi Kaoru Kubota Akihiko Gemma
Departmemt of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School
ABSTRACT
Talc was recently approved as a treatment agent for malignant pleural effusion in Japan. In this retrospective study, we evaluated the efficacy and safety of talc compared with OK-432 in the treatment of malignant pleural effusion. Thirty patients with malignant pleural effusion were treated with talc, and another 30 were treated with OK-432. Pleurodesis success rates did not significantly differ between the OK-432 and talc groups (79.2% vs. 69.2%, p=0.42). The frequencies of fever and chest pain as adverse events were significantly lower in the talc group than in the OK-432 group (p<0.01, p<0.05, respectively). Talc-related lung injury was found in 2 cases, but they were immediately improved by steroid therapy. These findings suggest that talc may be a safe and effective agent for chemical pleurodesis in patients with malignant pleural effusion.
KEYWORDS
Malignant pleural effusion Pleurodesis Talc OK-432
Received 7 Apr 2016 ／ Accepted 22 Jul 2016
AJRS, 5(6): 297-301, 2016
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