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Article in Japanese
Abstract
Case Report
A case of lung injury induced by infliximab during treatment for ulcerative colitis
Hiroaki Matsuura Keiichi Fujiwara Hiromi Watanabe Ken Sato Toshio Sato Takuo Shibayama
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center
ABSTRACT
A 25-year-old woman who received infliximab (IFX) therapy for refractory ulcerative colitis was admitted to our hospital with complaints of exertional dyspnea. Computed tomography scans of the chest showed nonsegmental ground-glass opacity and infiltrates in both lower lobes. Pathological examination of specimens obtained by transbronchial lung biopsy showed interstitial changes that were consistent with organizing pneumonia (OP). Because the lymphocyte stimulation test was positive for IFX, a diagnosis of IFX-induced lung injury was made. The patient was treated with prednisolone and her symptoms gradually improved. The incidence of IFX-induced lung injury is lower than pulmonary infection. Therefore we present an interesting case of IFX-induced lung injury, with pathological and radiological findings of OP, during treatment for ulcerative colitis.
KEYWORDS
Infliximab Ulcerative colitis Drug-induced lung injury Organizing pneumonia Drug-induced lymphocyte stimulating test
Received 26 Mar 2016 ／ Accepted 11 Jun 2016
AJRS, 5(5): 255-258, 2016
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