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Article in Japanese
Abstract
Review
Activation of influenza virus by airway epithelial proteases: a potential treatment for influenza
Mutsuo Yamayaa Yukimasa Hatachib Yoshitaka Shimotaic Morio Hommad Hidekazu Nishimurad
aDepartment of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine
bDivision of Respiratory Medicine and Oncology, Kobe City Medical Center General Hospital
cDepartment of Infectious Diseases, Yamagata University Faculty of Medicine
dVirus Research Center, Clinical Research Division, Sendai Medical Center
ABSTRACT
Proteolytic activation of influenza virus hemagglutinin by type II transmembrane serine proteases, which are expressed in the airway epithelial cells, enhances the release of viral RNA into cytoplasm, resulting in the next steps of viral replication. This replication and the release of inflammatory cytokine are associated with symptoms, including fever, disease severity, and exacerbation of bronchial asthma and chronic obstructive pulmonary diseases. Because serine protease inhibitors reduce influenza viral replication and cytokine release, the inhibitors are potential candidates for anti-influenza virus drugs.
KEYWORDS
Serine protease Influenza virus Airway epithelial cells Airway inflammation
Received 19 Feb 2016 ／ Accepted 16 Mar 2016
AJRS, 5(4): 172-183, 2016
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