A 65-year-old woman was found to have a 42-mm-diameter mass in the right inferior lobe on chest computed tomography. She was diagnosed as having pulmonary adenocarcinoma (cT2aN3M1a, Stage IV) with epidermal growth factor receptor mutation (exon 19 deletion). Gefitinib was administered, which significantly reduced tumor size and eliminated metastatic lesions. A new mass shadow was recognized in the right inferior lobe 2 years and 6 months after initiation of treatment. She underwent salvage surgery, followed by platinum-based adjuvant chemotherapy. Local recurrence was noted 2 years 2 months after surgery, and the tumor obviously increased in size 9 months after recurrence was first noted. Pathological examination of the resected tissue showed weak tumor-feeding vessels, and chemotherapy, including bevacizumab, was administered, which resulted in complete remission. Six years 9 months since the start of therapy, she is alive with a performance status of 0.