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Article in Japanese
Abstract
Case Report
Acute aortic thrombosis in pulmonary adenocarcinoma patients receiving cisplatin-based chemotherapy
Ryota Aokia Kousuke Kashiwabaraa Shinji Fujiia Shinsuke Tsumuraa Hiroshi Sembaa Eiichiro Tanakab
aDepartment of Respiratory Medicine, Kumamoto Regional Medical Center
bSenda Medical Clinic
ABSTRACT
A 64-year-old man was diagnosed as having pulmonary adenocarcinoma (cT1bN3M1b; stage IV) in the left upper lobe accompanied with chronic pulmonary thromboembolism. He was treated with intravenous cisplatin (75 mg/m2) and pemetrexed (500 mg/m2) in combination with continuous intravenous drip infusion of heparin (200 units/kg). Three weeks after completion of the first cycle, enhanced CT imaging of the chest showed a large aortic thrombus at the aortic arch in spite of decreased size of the tumor and mediastinal lymphadenopathy. In the absence of predisposing factors, we diagnosed a silent acute aortic thrombosis caused by cytotoxic anticancer agents containing cisplatin. The cytotoxic chemotherapy was continued with an administration of warfarin potassium (6.5 mg/day). Follow-up CT 3 months later revealed complete resolution of the thrombus.
KEYWORDS
Non-small cell lung cancer Acute aortic thrombosis Cisplatin containing regimen
Received 16 Dec 2014 ／ Accepted 3 Apr 2015
AJRS, 4(4): 288-292, 2015
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