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Abstract
Case Report
Successful treatment in a case of interstitial lung disease with clinically amyopathic dermatomyositis with positive anti-CADM-140/MDA5 antibodies by the administration of prednisolone, cyclosporin A, and mycophenolate mofetil
Kenjiro Shimaa Takuro Sakagamia Kosuke Ichikawaa Satoshi Hokaria Katsuaki Asakawaa Toshiyuki Koyaa Hiroshi Kagamua Toshinori Takadab Ichiei Naritaa
aDivision of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University
bUonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital
ABSTRACT
A 29-year-old woman was admitted to Niigata University Medical and Dental Hospital. She was diagnosed as clinically amyopathic dermatomyositis (CADM), showing Gottron sign on fingers, telangiectasia around nails, less myogenic symptom, and positive anti-CADM-140/MDA5 antibodies. Also, a chest CT scan showed interstitial lung disease (ILD) as one of the comorbidities. She was treated with oral prednisolone, cyclosporin A, and mycophenolate mofetil (MMF). The treatment was well tolerated and induced improvement of the disease. A concentration of anti-CADM-140/MDA5 antibodies in serum was decreased. Although treatment for CADM-ILD has not been established, MMF might be one of the effective drugs for this disease.
KEYWORDS
Interstitial lung disease Clinically amyopathic dermatomyositis Anti-CADM-140/MDA5 antibodies Mycophenolate mofetil
Received 11 Jul 2014 ／ Accepted 8 Sep 2014
AJRS, 4(1): 76-80, 2015
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