Invasive aspergillosis causes systemic disseminated fungal infection. Most patients of this disease are immunocompromised hosts. The clinical courses are often progressive, and the patients develop very serious illnesses, so we should start treatment in the early clinical course. We have experienced a case of invasive aspergillosis in a male patient. He had no record of immune system illness or diseases that caused immunodeficiency, but he had experienced lymphocytopenia. He became worse over a short term and died. A pathological autopsy revealed disseminated aspergillus infection in multiple organs and hemophagocytosis in the bone marrow. Few case reports of invasive aspergillosis caused in immunocompetent hosts are available. If a patient shows atypical chest images or symptoms of hemoptysis, pulmonary aspergillosis should be suspected and, if needed, judicious antifungal therapy initiated.