Correlations between computed tomography images and respiratory function in chronic obstructive pulmonary disease
Satoru Ishiia Haruhito Sugiyamaa Teruo Kirikaeb Haruna Masakia Go Nakaa Motoyasu Iikuraa Yuichiro Takedaa Masayuki Hojoa
aDepartment of Respiratory Medicine, National Center for Global Health and Medicine
bDepartment of Infectious Diseases, Research Institute, National Center for Global Health and Medicine
Although respiratory function tests are the primary method of assessing chronic obstructive pulmonary disease (COPD), the assessment of low-attenuation areas (LAA) on chest computed tomography (CT) has also been reported to facilitate assessment of prognosis. Our hospital installed Lung Vision® automatic analysis software, which visualizes LAA in yellow on chest CT and enables quantitative assessment. A total of seven patients met the exclusion criteria [improvement of forced expiratory volume in 1 s (FEV1) by ≥12% or ≥200 ml following inhalation of a β2 agonist (salbutamol sulfate) in four patients and test discontinuation because of metastatic lung tumor and other reasons in three patients]. Chest CT and respiratory function tests were conducted in 45 patients, and the results were assessed to determine the presence of correlations. A significant correlation (p<0.01) was observed between the Lung Vision score and FEV1/FVC, FEV1.
COPD Low attenuation area Low attenuation area volume
Received 4 Sep 2013 / Accepted 19 Nov 2013
AJRS, 3(2): 221-226, 2014