Clinical characteristics of chronic hypersensitivity pneumonitis with emphysema
Tomoyuki Ogataa,b Kimitake Tsuchiyaa Masahiro Ishizukaa Tsukasa Okamotoa Tsuyoshi Shiraia Masahiro Masuoa Toshiharu Tsutsuia Hiroyuki Sakashitaa Yasunari Miyazakia Naohiko Inasea
aDepartment of Integrated Pulmonology, Tokyo Medical and Dental University
bDepartment of Respiratory Medicine, JA Toride Medical Center
In this study we retrospectively analyzed the clinical characteristics of chronic hypersensitivity pneumonitis (CHP) with emphysema. Patients with CHP (n=161) diagnosed at our hospital were classified into two groups: CHP with emphysema [CHP-E(+) group] and CHP without emphysema [CHP-E(-) group]. The CHP-E(+) group consisted of 53 cases (33%) and had a higher frequency of men (92%) and a higher frequency of smokers (96%). The %DLco (54±25%) and %DLco/VA (56±22%) in pulmonary function tests were low, while %FVC (82±18%) and FEV1/FVC (78±9%) were normal. There were no differences between groups in the incidences of pulmonary hypertension or acute exacerbation of interstitial pneumonia, and the incidence of lung cancer was significantly higher in the CHP-E(+) group than in the CHP-E(-) group (24.5% vs. 4.6%, p<0.0001). The CHP-E(+) group manifested features observed earlier in patients with combined pulmonary fibrosis and emphysema.
Combined pulmonary fibrosis and emphysema Chronic hypersensitivity pneumonitis Pulmonary emphysema Primary lung cancer
Received 20 Aug 2013 / Accepted 28 Oct 2013
AJRS, 3(2): 214-220, 2014