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Abstract
Original Article
Procalcitonin as a diagnostic and prognostic marker of pneumonia in adults
Yoshihiro Yamamotoa,b Kohji Hashiguchic Toyomitsu Sawaid Yuichi Fukudae Yuichi Inouef Kiyoyasu Fukushimag Katsunori Yanagiharah Shigeru Kohnob
aDepartment of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences, Toyama University
bDepartment of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University
cDepartment of Internal Medicine, Japanese Red Cross Nagasaki Genbaku Hospital
dDepartment of Respiratory Medicine, Ureshino Medical Center
eDepartment of Respiratory Medicine, Sasebo City General Hospital
fDepartment of Respiratory Medicine, Isahaya Health Insurance General Hospital
gDepartment of Respiratory Medicine, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital
hDepartment of Laboratory Medicine, Nagasaki University Hospital
ABSTRACT
A total of 263 patients with community-acquired pneumonia, hospital-acquired pneumonia, or healthcare-associated pneumonia were enrolled in the study. Initial procalcitonin (PCT) value increased with pneumonia severity, as assessed by the pneumonia severity index (PSI); however, C-reactive protein value and white blood cell count were not related to it. No significant differences of initial PCT value were seen among etiological agents. However, in H. influenzae and S. pneumoniae groups, PCT value was increased in the severe group. In distinguishing between nonsurvivors and survivors in patients after antibiotic treatment, the area under the curve was 0.983 for PCT. These findings suggest that PCT is a powerful indicator of disease severity and prognosis assessment in pneumonia patients.
KEYWORDS
Community-acquired pneumonia Hospital-acquired pneumonia Healthcare-associated pneumonia Procalcitonin Prognostic predictor
Received 22 May 2013 ／ Accepted 3 Oct 2013
AJRS, 3(1): 50-55, 2014
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