A 77-year-old woman with chronic myeloid leukemia was treated with 400 mg/day of imatinib mesylate from November 2, 2010. She had dyspnea from March 2011. On April 12, reticular opacities appeared in her chest X-ray, and her symptoms got worse. The X-ray films and high-resolution computed tomography (HRCT) of her chest showed ground-glass opacities in the bilateral lung field with 2 cm of nodule in the right S⁶_b segment with 4 small nodules. These findings suggested imatinib-induced pneumonitis with some infectious or granulomatous disease. Imatinib was discontinued from April 25. A transbronchial lung biopsy specimen from ground-glass opacities and an endobronchial ultrasound-guided sheath biopsy specimen from a big nodule demonstrated both interstitial pneumonia findings. Under diagnosis of imatinib-induced pneumonitis with nodules, 30 mg/day of prednisolone was given from April 29. The ground-glass opacities disappeared 4 weeks later, and it took 3 months to improve a big nodule by HRCT of her chest. Reports of imatinib-induced pneumonitis with nodules are becoming less frequent. It was necessary to treat the above pneumonitis by steroid therapy because improvement of the nodular lesion took longer than that of ground-glass opacities.