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Article in Japanese
Abstract
Case Report
A case of hyperimmunoglobulin E syndrome with a history of repeated respiratory tract infection and a gene mutation of signal transducer and activator of transcription 3
Yuichi Kurakamia Akimasa Sekinea Koji Okudelab Tsuneyuki Odaa Eri Hagiwaraa Tomohisa Babaa Takashi Oguraa
aDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center
bDepartment of Pathology, Graduate School of Medicine, Yokohama City University
ABSTRACT
A 43-year-old female patient, with a history of repeated skin abscess and four-time hospitalization because of pneumonia from childhood, visited our hospital. At age 39, she gave birth to her first baby, who presented with refractory rash three weeks after birth and was found to have a high serum IgE level and gene mutation of signal transducer and activator of transcription 3 (STAT3). Both a high serum IgE level and the same gene mutation were also recognized in the patient. At her first visit to our hospital, severe bronchodilation at the left lower lobe was present, and mucoid Pseudomonas aeruginosa was repetitively isolated from her sputum. Because of repeated respiratory tract infection, she underwent a left lower lobectomy. Although STAT3 mutation is rare, its presence should be considered for patients with a history of repeated respiratory tract infection.
KEYWORDS
Hyper immunoglobulin E syndrome Signal transducer and activator of transcription 3 (STAT3) Pseudomonas aeruginosa
Received 13 Mar 2013 ／ Accepted 7 Aug 2013
AJRS, 2(6): 773-777, 2013
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