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Article in Japanese
Abstract
Case Report
A case of cytomegalovirus enteritis developed during chemotherapy for small-cell lung cancer
Akio Komuro Kunihiko Shimizu Keisuke Imasaka Hiroki Takakura Kanako Hirayama Nobuyuki Hamanaka
Division of Respiratory, Saiseikai Yokohamashi Tobu Hospital
ABSTRACT
A 78 year-old man with advanced small-cell lung cancer, previously treated by carboplatin plus etoposide with minor response, was treated by second-line chemotherapy with carboplatin plus irinotecan. On day 8, he developed worsening diarrhea, paralytic ileus, followed by massive melena. Investigation by gastroenterological endoscopy and abdominal CT scan revealed bleeding from the ileum. With the positive result of the cytomegalovirus (CMV) antigenemia, a diagnosis of CMV enteritis was made. Immediate administration of ganciclovir improved his symptoms and prevented sepsis. We consider it important to diagnose and start treatment for CMV enteritis when patients develop refractory and unexplainable diarrhea in the course of chemotherapy for lung cancer.
KEYWORDS
Small-cell lung carcinoma Irinotecan Cytomegalovirus enteritis
Received 28 Dec 2012 ／ Accepted 31 May 2013
AJRS, 2(5): 567-572, 2013
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