Annals of The Japanese Respiratory Society:Eosinophilic pleural effusion resulting from propylthiouracil

Vol.2 No.4 Table of Contents

Abstract

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Article in Japanese

Case Report

Eosinophilic pleural effusion resulting from propylthiouracil

Nobuo Ishiwata^a Yuko Taniguchi^a Naohiko Inase^b

^aInternal Medicine, Kudanzaka Hospital
^bDepartment of Respiratory Medicine, Tokyo Medical and Dental University

ABSTRACT

A 55-year-old man was admitted to our hospital with a complaint of slight left chest pain and dyspnea on effort of 2 months duration. He had had Basedow's disease, which had been treated with high-dose (300 mg daily) propylthiouracil (PTU) for 15 years. Chest X-ray on admission showed left moderate pleural effusion, and thoracentesis revealed eosinophilic pleural effusion (EPE). After normalization of the thyroid hormone and the anti-TSH receptor antibody had been confirmed, PTU was decreased gradually and discontinued. Since then, pleural effusion has disappeared without recurrence. We conclude that in this case, EPE was induced by a long-term use of PTU.

KEYWORDS

Eosinophilic pleural effusion Propylthiouracil

Received 22 Nov 2012 ／ Accepted 7 Mar 2013

AJRS, 2(4): 437-441, 2013

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