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Abstract

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Article in Japanese

Case Report

A case of small cell lung cancer complicated with subacute sensory neuropathy and membranous nephropathy

Hiroshi Ito  Kazuhiko Machida  Chie Komura  Sachiko Ozone  Daizo Yaguchi  Akihiro Matsushita  Masaki Matsuo 

Department of Respiratory Internal Medicine, Japan Labour Health and Welfare Organization Chubu Rosai Hospital

ABSTRACT

A 67-year-old man had been suffering from membranous nephropathy and sensory neuropathy for 1 year. He was at first suspected of paraneoplastic syndrome, so a systemic examination was performed. But a tumor was not detected. He was treated with glucocorticoid and intravenous immunogloblin for sensory neuropathy. But there was little effectivity. More than one year after he diagnosed sensory neuropathy and membrous nephropathy, a CT scan was performed again, and it showed left lower lobe nodule and mediastinal lymph node swelling. As the result of transbronchial lung biopsy, he was given a diagnosis of small cell lung cancer. The clinical stage was cT1aN3M1b-stage IV OSS. Anti-Hu antibody was checked and found positive. His sensory neuropathy was diagnosed as paraneoplastic neurological syndrome complicated by small cell lung cancer. He was treated with chemotherapy, and a clinically complete response was obtained. Nephrosis was remitted, but sensory disorder was not. He has visited our hospital regularly without recurrence of his cancer. We reported a case in which two types of paraneoplastic syndrome were complicated.

KEYWORDS

Small cell lung cancer  Paraneoplastic neurological syndromes  Subacute sensory neuronopathy  Anti-Hu antibody  Membranous nephropathy 

Received 18 Jun 2012 / Accepted 25 Jan 2013

AJRS, 2(4): 349-353, 2013

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