A case of small cell lung cancer complicated with subacute sensory neuropathy and membranous nephropathy
Hiroshi Ito Kazuhiko Machida Chie Komura Sachiko Ozone Daizo Yaguchi Akihiro Matsushita Masaki Matsuo
Department of Respiratory Internal Medicine, Japan Labour Health and Welfare Organization Chubu Rosai Hospital
A 67-year-old man had been suffering from membranous nephropathy and sensory neuropathy for 1 year. He was at first suspected of paraneoplastic syndrome, so a systemic examination was performed. But a tumor was not detected. He was treated with glucocorticoid and intravenous immunogloblin for sensory neuropathy. But there was little effectivity. More than one year after he diagnosed sensory neuropathy and membrous nephropathy, a CT scan was performed again, and it showed left lower lobe nodule and mediastinal lymph node swelling. As the result of transbronchial lung biopsy, he was given a diagnosis of small cell lung cancer. The clinical stage was cT1aN3M1b-stage IV OSS. Anti-Hu antibody was checked and found positive. His sensory neuropathy was diagnosed as paraneoplastic neurological syndrome complicated by small cell lung cancer. He was treated with chemotherapy, and a clinically complete response was obtained. Nephrosis was remitted, but sensory disorder was not. He has visited our hospital regularly without recurrence of his cancer. We reported a case in which two types of paraneoplastic syndrome were complicated.
Small cell lung cancer Paraneoplastic neurological syndromes Subacute sensory neuronopathy Anti-Hu antibody Membranous nephropathy
Received 18 Jun 2012 / Accepted 25 Jan 2013
AJRS, 2(4): 349-353, 2013