Pulmonary actinomycosis manifesting malignant tumor pathologically mimicking inflammatory myofibroblastic tumor in a girl
Yasumiko Sakamotoa Keisuke Kojimaa Hidenori Ichiyasua Nahoko Satoa Shinichiro Okamotoa Tadashi Ananb Yoichiro Kobashic Ken-ichi Iyamad Hirotsugu Kohrogia
aDepartment of Respiratory Medicine, Kumamoto University Hospital, Faculty of Life Sciences, Kumamoto University
bDepartment of Pediatrics, Kumamoto University Hospital, Faculty of Life Sciences, Kumamoto University
cDepartment of Pathology, Tenri Hospital
dDepartment of Surgical Pathology, Kumamoto University Hospital, Faculty of Life Sciences, Kumamoto University
A 14-year-old girl complained of back pain and weight loss. Laboratory data showed increased white blood cells, C-reactive protein, and erythrocyte sedimentation rate (ESR). Her chest radiograph and computed tomography (CT) scan showed a large tumor with satellite lesions in the right upper lung that had spread to the back muscle and invaded the left hemithorax through the mediastinum, suggesting malignancy. A CT-guided percutaneous tumor biopsy showed chronic inflammation with sulfur granules consistent with actinomycosis. It also showed the increase of α-smooth actin positive spindle-shaped cells, suggesting an inflammatory myofibroblastic tumor. She was treated with antibiotic tazobactam-piperacillin following cefozopran, and then amoxicillin. Her laboratory data improved, and the tumor disappeared. Therefore the diagnosis was confirmed as pulmonary actinomycosis, which is a disease frequently misdiagnosed and is quite rare in children. It should be kept in mind, however, when a pulmonary tumor is found with inflammatory manifestation in laboratory and pathological data, even in children.
Pulmonary actinomycosis Inflammatory myofibroblastic tumor Sulfur granule
Received 1 May 2012 / Accepted 7 Aug 2012
AJRS, 2(3): 205-210, 2013