A case of sarcoidosis associated with rheumatoid arthritis
Fumio Kurosakia Masashi Bandoa Tamiko Takemurab Naoko Matoa Hideaki Yamasawaa Yoshinobu Eishic Yukihiko Sugiyamaa
aDivision of Pulmonary Medicine, Department of Medicine, Jichi Medical University
bDepartment of Pathology, Japanese Red Cross Medical Center
cDepartment of Human Pathology, Tokyo Medical and Dental University
A 46-year-old woman presented at a local hospital with polyarthralgia and dyspnea on exertion. She was referred to our hospital on suspicion of rheumatoid arthritis with interstitial pneumonia, according to her chest X-ray. Biopsy specimens obtained by video-assisted thoracoscopic surgery (VATS) and skin biopsy showed noncaseating epithelioid cell granulomas consistent with sarcoidosis. We therefore considered that this could be a case of polyarthralgia of sarcoidosis with articular involvement. Four years later she was diagnosed with rheumatoid arthritis because of articular erosion and atlanto-axial subluxation. We reviewed the earlier biopsy specimens obtained by VATS, which showed not only granulomas, but also follicular bronchiolitis. We therefore concluded that sarcoidosis and rheumatoid arthritis had already coexisted at that time. When articular involvement and interstitial pneumonia are found in patients with sarcoidosis, we should consider the possibility of coexistence of rheumatoid arthritis.
Sarcoidosis Articular involvement Rheumatoid arthritis Interstitial pneumonia
Received 12 Apr 2012 / Accepted 20 Jul 2012
AJRS, 2(2): 128-133, 2013