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Article in Japanese
Abstract
Case Report
Drug-induced pneumonia possibly associated with temsirolimus
Hisako Kushima Hiroshi Ishii Atsushi Yokoyama Satoshi Toba Issei Tokimatsu Jun-ichi Kadota
Internal Medicine 2, Oita University Faculty of Medicine
ABSTRACT
A 55-year-old male with a 9-year treatment history of advanced renal cell carcinoma was treated for metastatic mediastinal lymphadenopathy with temsirolimus, a specific inhibitor of the mammalian target of rapamycin (mTOR). A month after the initiation of temsirolimus administration (25 mg/week), the patient started to reveal pyrexia, malaise, and dyspnea. A chest computed tomography taken after an additional month showed interstitial pneumonia. Laboratory tests showed an inflammatory reaction, liver dysfunction, and a high serum level of KL-6. There was lymphocytosis in the bronchoalveolar lavage fluid. This course suggested that temsirolimus caused drug-induced pneumonia, and the patient had been successfully treated with corticosteroids. In Japan, more cases of mTOR inhibitor-induced pneumonia should be collected for the proper and safe usage of temsirolimus.
KEYWORDS
Renal cell carcinoma Temsirolimus Drug-induced pneumonia
Received 2 Dec 2011 ／ Accepted 25 Apr 2012
AJRS, 1(7): 558-561, 2012
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